James (Jay) Brophy

Professor of Medicine & Epidemiology

McGill University


Jay Brophy is a tenured (full) professor with a joint appointment in the Departments of Medicine and Epidemiology and Biostatistics where he works as a clinical cardiologist and does research in cardiovascular epidemiology. His research interests are eclectic and include outcomes research, pharmacoepidemiology, health technology assessment, economic analyses and clinical research which are supported partially through a FRQS chair in health technology assessment and evidence-based medicine.


  • Outcomes research
  • Pharmacoepidemiology
  • Health technology assessment (Bayesian statistics)


  • PhD Epidemiology & biostatistics

    McGill University

  • Cardiology

    Université de Montreal

  • MD

    McMaster University

  • M.Eng.

    McMaster University

  • B.Eng.

    McGill University

Experience / CV



McGill University

Jul 2001 – Present Montreal QC
Joint appointment Deptartments of Medicine and Epidemiology & Biostatistics

  • Short CV
  • Most recent course - Intermediate Epidmeiology (EPIB 603 Winter 2020) syllabus


McGill University Health Center

Jul 2001 – Present Montreal QC

Non-invasive cardiologist
Clinical responsibilities include:

  • Coronary Care Unit (CCU)
  • Consultations

Non-clinical responsibilities include:

Recent Publications

Additional publications - see CV


Journal Article from 2020

Bayesian analysis of recent clinical trial, interpreted in the context of both vague and informative priors.

Journal Article from 2019

Cohort study showing the variability of hs-cTnT in stable patients according to clinical phenotypes.

Recent Posts

EXCEL - clearing the haze with Bayes

Yesterday I saw a MEDSCAPE article published last fall “Is the Tide Turning on the ‘Grubby’ Affair of EXCEL and the European …

Update on the science behind masks

While there is no doubt regarding the physical, mental, and economic carnage due to severe acute respiratory syndrome coronavirus 2 …

COVID, masks and poor science

A CDC report that concludes “face masks, evidence from randomized controlled trials of these measures did not support a substantial …

Pharma, bribes and MDs

$678 million fine testifies to how well these pharma bribes work, including the so-called CME events. Any bets that this is continuing …

Glad to be at the back of the queue

June 30 headlines reported that the US had bought all the reserves of remdesivir, leaving none for “the next three months of one of the …

Recent Talks

A Bayesian Approach to Left Main Disease – How has the Excel Trial moved the needle?

Talk from joint cardiovascular rounds.

Meta-analysis Lecture

Meta-analysis - Online lecture (April 2020)

Debate: Be it Resolved: Chronic Total Occlusions Remain Closed

Talk from a symposium on high value medical care.


Previous accomplishements (2019)

Previous accomplishements (2020)

Accomplishements (2021)

Matching and Weighting for Causal Inference with R

Quasi-experimental techniques of matching and weighting methods using R to estimate causal effects from observational data

Machine Learning

Within R framework, topics included cross-validation and and advanced variable selection methods for regression analysis


(Mostly) Clinical Epidemiology with R

First 10 chapters of my online E book, (Mostly) Clinical Epidemiology with R, created with Bookdown (other chapters to follow)

TC4: Ticagrelor compared to clopidogrel in acute coronary syndromes - the TC4 comparative effectiveness study

CIHR funded project looking at the comparative effectiviness of ticagrelor versus clopidogrel in acute coronary syndromes


  • 514 934-1934 ext 36771
  • 5252 Boul. de Maisonneuve West, Room 2B.37, Montreal, QC H4A 3S5
  • Enter Building and take the stairs to Floor 2 then buzz
  • Office hours Wednesday 14:00 to 16:00
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  • Skype Me